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Smog hit the mouse’s nose. The experiment showed how dangerous dust is for people after a stroke

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Smog has a very negative impact on our health. Until now, however, scientists did not know what its consequences could be in the event of a stroke. To this end, a team of Japanese scientists conducted observations on mice.

Air pollution with aromatic hydrocarbons increases inflammation and movement disorders after ischemic stroke, according to a study published in the scientific journal “Particle and Fiber Toxicology”.

Air pollution is known to have a negative impact on the prognosis of ischemic stroke (caused by reduced blood flow to the brain). However, the exact mechanism has not yet been known.

As research by scientists from Hiroshima University suggests, the main culprit may be inflammation of the brain. ‘We designed this study to determine the effects of air pollution on disorders in the central nervous system. We also wanted to determine whether air pollution affected the prognosis of ischemic stroke, said Yasuhiro Ishihara, the lead author of the paper and a professor at Hiroshima University.

Cities with the most smog days in 2021PAS, CIEP

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The observations lasted a week

In the first set of experiments, mice were exposed to intranasal city aerosols from Beijing, the capital of China, which is known for its high levels of air pollution.

After a week of exposure, the mice showed signs of increased neuroinflammation and worsened movement disorders after ischemic stroke compared to control mice that were not exposed to air pollution. Under the influence of pollutants in the air, microglia cells, which are immune cells in the brain, were activated.

The second set of experiments involved replacing air pollution from Beijing with PM2.5 dust, sourced from Yokohama, Japan. The results were similar, suggesting that the fraction of PM2.5 pollutants in urban air contains a substance responsible for increased neuroinflammation and poorer prognosis in case of stroke.

This effect was not seen in mice lacking a receptor for chemicals released by the burning of fossil fuels, wood, garbage and tobacco, called polycyclic aromatic hydrocarbons (PAHs).

Mice lacking the PAH receptor showed lower microglial activation and movement disorders compared to normal mice, suggesting that airborne PAHs are responsible for at least some of the neuroinflammation and poorer prognosis seen in ischemic stroke mice exposed to air pollution .

Poles about smogAdam Ziemienowicz/PAP

Main photo source: Shutterstock

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